We also found that the ALS/FTLD causative gene products are classified into three groups: gene products that induce co-aggregates with TDP-43 (Group 1) (Fig. 1C, F, G), gene products that induce aggregates without TDP-43 (Group 2) (Fig. 1D, F, G), and gene products that do not form aggregates (Group 3) (Fig. 1E–G). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.