Cox model analysis of 954 antiretroviral therapy-naïve HIV-1 seroconverters revealed a significant association between higher global TD and more rapid progression to AIDS as defined by the CDC in 1987 (AIDS-1987), after adjusting for race and HLA-B*57/27/35Px alleles (HR = 1.5 per one log10 increase in global TD score, P = 0.001; Table 2 and Fig. 3A), which are known to affect AIDS progression in this cohort (30). This evidence concerns the gene HLA-B and AIDS.