CD8A and autoimmune disease: DNA from DN T cells and the precursor CD8+ T cells ofB6-lpr mice were subjected to reduced representationbisulfite sequencing (RRBS) (17).B6-lpr mice were chosen over MRL-lpr mice,as B6-lpr mice develop only minimal if any lupusmanifestations, allowing better separation of the epigenetic findings frompotential confounding processes driven by autoimmune disease.