GJA1 and congestive heart failure: The pathophysiology of acute myocardial infarction and consequent progression into chronic heart failure have been associated with altered trafficking of Cx43-containing GJs, many of these being correlated with changes in the phosphorylation and ubiquitination profile of Cx43 (Fong et al, 2013; Smyth et al, 2014; Martins-Marques et al, 2015a, 2015b, 2015c, 2020; Ribeiro-Rodrigues et al, 2017b).