Recently, patients with STUB1 ataxia were shown to present a broader neurodegeneration with complex clinical phenotypes of cognitive impairment, epilepsy and hypogonadism in addition to spastic-ataxic movement disorder (Shi et al., 2013; Heimdal et al., 2014; Shi et al., 2014; Synofzik et al., 2014; Hayer et al., 2017). Here, STUB1 is linked to epilepsy.