As for molecular alterations, epigenetic gene mutations are frequently observed in DLBCL, mainly including histone methyltransferases KMT2C, KMT2D, and EZH2, histone acetyltransferases CREBBP, EP300, and IRF4, chromatin remodeler HIST1H1E and ARID1A, and DNA methylation gene TET2 [9]. Here, CREBBP is linked to diffuse large B-cell lymphoma.