HIF-1α is a master transcriptional factor that controls tumor metabolic reprogramming, given that HIF-1α target genes HK2, Glut1 and MCT4 [30], major enzymes of glycolytic pathway, were elevated in etoposide-treated NSCLC cells (Fig. 1c), we explored whether etoposide also impacted HIF-1α expression. This evidence concerns the gene HK2 and neoplasm.