Possible explanations for the reduced rates of HIV in SCD may include inhibition of human immunodeficiency virus (HIV) replication due to the pro-inflammatory status of SCD patients [5], influence of Duffy antigen on HIV-1 capability of infecting SCD host cells [6], HIV-1 transcription and replication inhibition in SCD patients’ cells due to increased ferroportin expression and reduced intracellular iron [7], or an increased expression in SCD of CCR5Δ32 [8] that promotes resistance to HIV infection. This evidence concerns the gene SLC40A1 and HIV infectious disease.