GP5 and cancer: Even though most of the HR-HPV assays approved for primary cancer screening are based on HR-HPV DNA detection, like the Hybrid Capture 2 (HC2) method or the GP5+/6 + EIA assay or the COBAS® there is now growing evidence that HR-HPV detection methods targeting the mRNA of the oncoproteins E6/E7 are also effective and reliable alternative screening tools [13–18].