For example, hesperidin (approximately 10 μM) found in C. tangerine peel suppressed lipopolysaccharide-induced ERK1/2 phosphorylation in HaCaT cells [44], and naringin (100 μM) isolated from C. grandis attenuated EGF-induced ERK1/2 phosphorylation in human lung adenocarcinoma cells [45]. The gene discussed is MAPK3; the disease is lung adenocarcinoma.