On the other hand, it was reported that hesperidin (40 μM), naringin (100 μM), and hesperetin (50 μM) facilitated ERK1/2 phosphorylation in normal human hepatic cells, human bladder carcinoma cells, and murine B16-F10 melanoma cells, respectively [47,48,49]. Here, MAPK3 is linked to melanoma.