The ENTIRE-TIMI 23 study, comprising 314 patients with ST-elevation myocardial infarction (STEMI) in whom the plasma levels of vWF were measured before and 48–72 h after fibrinolysis, showed that an increase in vWF levels after fibrinolysis was associated with the higher mortality and MI rate in 30 days (11.2% vs. 4.1%, respectively) [67]. The gene discussed is VWF; the disease is ST Elevation Myocardial Infarction.