The prospective PRIME study, comprising nearly 10,000 healthy men, among whom 296 developed CAD during the 5 years of follow-up (158 persons with MI and 142 with stable and unstable angina), showed that the baseline plasma levels of vWF were significantly higher in men who developed MI (129.2 ± 53.1 IU/dL) compared to the healthy controls (115.9 ± 41.8 IU/dL) [73]. This evidence concerns the gene VWF and myocardial infarction.