A myocardial ischemia/reperfusion study in ADAMTS-13-knockout mice showed that infusion of recombinant ADAMTS-13 substantially reduced myocardial apoptosis, troponin-I release, and resulted in a 9-fold reduction in the number of neutrophils infiltrating the ischemic zone [32]. The gene discussed is ADAMTS13; the disease is myocardial ischemia.