Considering the high prevalence of breast cancer in women with diabetes [29,30], we studied if hyperglycemia could exacerbate ipilimumab-induced cardiotoxicity and decreases its anticancer efficacy in human breast cancer cells (estrogen responsive and triple negative cells) and verified the involvement of NLRP3 and MyD88 in these processes. The gene discussed is NLRP3; the disease is diabetes mellitus.