Effectively, under hyperglycemia, compared to low glucose, MCF-7 cells exposed to ipilimumab (Figure 8A) overexpressed IL-1β (245.5 ± 11.5 vs. 156.6 ± 3.4 pg/mg of protein, paired t-test p < 0.001, n = 3), IL-6 (173.3 ± 3.3 vs. 96.6 ± 6.7 pg/mg of protein, paired t-test p < 0.001, n = 3), PDGF (121.1 ± 8.3 vs. 72.3 ± 3.5 pg/mg of protein, paired t-test p < 0.001, n = 3), VEGF (182.5 ± 5.5 vs. 95.3 ± 3.8 pg/mg of protein, paired t-test p < 0.001, n = 3), and TGF-β (165.5 ± 8.5 vs. 97.7 ± 5.3 pg/mg of protein, paired t-test p < 0.001 n = 3). This evidence concerns the gene TGFB1 and Hyperglycemia.