However, given the substantial difference in absolute risks of relapse, the variant may prove useful once iTTP has been diagnosed, in combination with other markers of recurrence already available in the clinic (i.e., severe ADAMTS13 deficiency and positive anti-ADAMTS13 autoantibodies during remission) [10,11], in order to identify patients at high risk of iTTP relapse, who may benefit from a close monitoring or an intensified therapy. Here, ADAMTS13 is linked to hyperinsulinemic hypoglycemia, familial, 4.