CREB1 and cancer: The antagonism exerted by NRF2 on p65 translocation has been described in cancer cells, showing that simultaneous activation of p65 and NRF2 antagonize each other by competing for the co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)-p300 complex, leading to inhibition of the NRF2 pathway [93].