The risk of MI for the highest compared with the lowest quartile of CP was 2.46 (95% CI 1.04–6.00), a relationship that continued after making adjustments for other potential contributors, like C-reactive protein or leucocyte count (lowering a third of the effect), thus supporting the theory that the excess CP itself contributes substantially to the risk of CHD [16]. This evidence concerns the gene CRP and coronary artery disorder.