Because inflammation is recognized as a key player in atherosclerotic progression, Mori et al. separated the risk contributed by CP from that of inflammation (α1-antitrypsin, α1-acid glycoprotein, α2-macroglobulin, haptoglobin, fibrinogen, C4b binding protein, lipoprotein (a) and C-reactive protein (CRP)) and suggested that CP could serve as independent risk factor for coronary atherosclerosis and as a marker for the severity of disease [14]. This evidence concerns the gene CP and coronary atherosclerosis.