CUBN and diabetes mellitus: Therefore, reduced expression or loss of the cubilin–megalin complex may contribute to albuminuria of early diabetic kidney disease via reduced tubular reuptake of filtered albumin, which was supported by the observed association of rs1801239 with incident and persistent microalbuminuria in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study [35].