Vascular endothelial growth factor (VEGF) is the key player in the pathogenesis of choroidal neovascularisation (CNV) and tumour angiogenesis, with four different homodimeric proteins or isoforms formed by VEGF messenger RNA (mRNA) splicing, namely, VEGF121, VEGF165, VEGF189 and VEGF206 (based on the number of amino acids present). This evidence concerns the gene VEGFA and neoplasm.