Because transcription of the mutant EGFR transgenes was tetracycline-inducible and regulated by rtTA expressed downstream of the CCSP promoter both the [L858R]-hEGFR and the [L858R+T790M]-hEGFR bitransgenic mice developed lung-specific adenocarcinomas after several weeks of oral doxycycline administration. Here, EGFR is linked to adenocarcinoma.