EGFR and lung adenocarcinoma: In conclusion, in the present study, we showed that mice carrying inducible lung-specific L858R-hEGFR or [L858R+T790M]-hEGFR transgene containing the full-length of genomic EGFR developed lung adenocarcinomas and that L858R-hEGFR-associated lung adenocarcinomas acquired de novo T790 mutation without previous TKI therapy.