SCN1A variants are found associated with a continuum of epilepsy phenotypes such as intractable childhood epilepsy with generalized tonic-clonic seizures, including simple febrile seizures or familial fever-related epilepsies referred to as generalized epilepsies with febrile seizures and also a risk factor for common epilepsies like TLE and GGE [177]. This evidence concerns the gene SCN1A and Seizure.