One study employed a triple transgenic AD mice model with one harboring Swedish double mutation, beta-amyloid precursor protein (betaAPPSwe), presenilin-1 (PS1M146V), and human tauP301L [42], while the other was an APP knock-in mice (APPNL-G-F) that developed several features of AD [39]. The gene discussed is PSEN1; the disease is Alzheimer disease.