HDAC2 and type 2 diabetes mellitus: On the other hand, HDAC2 (9-fold, p < 0.001) was significantly decreased in DFU when compared to the NGT, and its expression was progressively downregulated in the uninfected (1-fold, p < 0.05) and infected DFU subjects (1.5-fold, p < 0.05) when compared to the T2DM.