It suggests that NRF2 is inversely correlated with the HDAC1, 3, 4 circuit and positively correlated with SIRT1. Furthermore, it also demonstrates that pro-inflammatory marker IL-6 is positively correlated with HDAC4 and negatively correlated with SIRT1. The HDAC expression profile and its association with NRF2 as well as inflammatory markers, are suggestive of clinicopathological characteristics of patients with T2DM and DFU. Here, HDAC4 is linked to type 2 diabetes mellitus.