Interestingly, another protein closely related to the first phase of autophagy initiation, ULK1 [40], was significantly decreased only in the LV of failing hearts (Figure 2E), while activating phosphorylation of ULK1 at Ser555 was significantly decreased due to HF in both ventricles of the heart (Figure 2F). The gene discussed is ULK1; the disease is hydrops fetalis.