The mRNA-binding protein of ELAV-family HuR is a valuable biomarker of brain tumor progression [48,49,50,51] and is involved in the regulation of the key cell-signaling pathways responsible for the inflammatory glioma microenvironment, the hypoxia-related stress response, the transitions of classic and proneural glioma subtypes to the mesenchymal subtype, the metabolic stress, and the reactive oxygen species (ROS) generation associated with D-2HG oncometabolite production in low-grade gliomas harboring single alleles with IDH1-R132H/C/S mutations [52,53,54,55]. The gene discussed is IDH1; the disease is central nervous system cancer.