Using a specific antibody that recognizes the highly homologous human TDP-43 ortholog in zebrafish [93], we importantly observed a mislocalization of TDP-43 from the nucleus to the cytoplasm in skeletal muscles of the c9orf72 loss-of-function model; consistent with TDP-43 pathology in ALS. Here, TARDBP is linked to amyotrophic lateral sclerosis.