Moreover, in our investigated population (pediatric patients and controls), only the frequency of homozygous genotype for AXIN1 rs12921862 was similar with the data reported in previous studies [15,18]; the frequency of heterozygous genotype was higher in our investigated population, leading to unsignificant results compared to Chinese Population (23.1% in ASD patients and 8.3% in controls reported by Yan Pu et al. [18], 37.1% in dilated cardiomyopathy patients and 8.6% in controls reported by Kai Li et al. [15], compared to 30.1% in our CHD patients and 40.5% in our controls). This evidence concerns the gene AXIN1 and atrial septal defect.