Moreover, there was a marginally significant unadjusted effect of AXIN1 rs1805105 variant in the recessive gene model (p = 0.048, OR = 0.51, 95% CI: 0.25–1.01) and after adjusting for maternal age group, AXIN1 rs1805105 gene variant was significantly associated with increased odds of ASD (p = 0.041, adjusted OR = 0.48, 95% CI: 0.24–0.99). This evidence concerns the gene AXIN1 and atrial septal defect.