Separately, in the univariate analysis, AXIN1 rs1805105 variant was not associated with CHD risk but our results for haplotype analysis suggest that in the case of C-C-C and C-C-T haplotypes, the risk effect is modulated by AXIN1 rs1805105 variant, with a higher risk for AXIN1 rs1805105 C allele. The gene discussed is AXIN1; the disease is coronary artery disorder.