In addition, the AXIN2 rs2240308 gene variant was a significant risk factor for ASD development under the allelic model (OR = 1.60, 95% CI: 1.05–2.44), while AXIN1 rs12921862 and AXIN1rs370681 gene variants were protective factors (Table 2). Here, AXIN1 is linked to atrial septal defect.