Efendić et al. [42] demonstrated a slightly lower insulin response in T2DM patients (iAUC, 21.66 μU/mL/min) compared to healthy individuals (iAUC, 22.49 μU/mL/min) who received intravenous arginine infusion, but the insulin concentrations remained elevated over a prolonged period of time in T2DM patients. The gene discussed is INS; the disease is type 2 diabetes mellitus.