In a follow up study, posiphen, a well-tolerated (+) enantiomer of phenserine (an anticholinesterase, AChE) and an APP 5’UTR-targeted small molecule (passing phase 1 clinical trials for AD), also blocked α-Syn translation via its 5’UTR both in neural SH-SY5 cells and in primary neurons from PAC-Tg SNCA mice expressing the human SNCA gene [123]. The gene discussed is APP; the disease is Alzheimer disease.