TFRC and major depressive disorder: Given SNCA’s role in cellular iron homeostasis, i.e., iron import in association with the transferrin receptor, its reported ferrireductase activity [136] as well as the occurrence of Iron Responsive Elements (IREs) on its regulatory 5’UTR region controlling its translation by iron [120], therapies that target SNCA may also be useful for the treatment of AUD, as well as related disorders such as anxiety and MDD, which have also been associated with iron dyshomeostasis [137,138].