AT1 receptor mRNA levels (that mediate vasoconstriction) were also significantly decreased in all the groups treated with CsA, and fosfomycin did not modify this behavior (Figure 6C), whereas AT2 receptor mRNA levels (that mediate vasodilation) were significantly increased in CsA-treated animals, but only reached statistical significance in the CsA + LF and the CsA + HF groups (Figure 6D). This evidence concerns the gene AGTR1 and hydrops fetalis.