Notably, hypoxic stress reprograms the expression of multiple miRNAs via activation of HIF1-α, and several additional RasGAP-targeting miRNAs, such as miR-107, miR-130, miR-145, and miR-335, are upregulated by hypoxic conditions, potentially favoring Ras activation and tumor progression [145]. The gene discussed is RASA2; the disease is neoplasm.