A recent report showed that EZH2-dependent DAB2IP repression induces a stem-like phenotype in ovarian cancer cells by unleashing WNT5B-dependent planar cell polarity signaling; this study also provides proof of concept that pharmacologic inhibition of EZH2 can restore DAB2IP expression and reduce stem features and aggressiveness of ovarian cancer cells [67]. The gene discussed is DAB2IP; the disease is ovarian cancer.