Specifically, NF1 is mutated in approximately 13% of cutaneous melanoma, together with inactivating the mutation of other tumor suppressor genes such as TP53, CDKN2A (cyclin dependent kinase inhibitor 2A), PTEN (phosphatase and tensin homolog), or RB1 (RB transcriptional corepressor 1) [38,39]. This evidence concerns the gene RB1 and cutaneous melanoma.