CD4 and asthma: For the top asthma-associated SNPs identified by PerturbNet, eCAVIAR, PrediXcan, and two-layer Lasso, we examined the functional annotations in three external resources (see Methods): the Encyclopedia of DNA Elements (ENCODE) DNase hypersensitivity sites (GSM1008572) in GM12878 B-lymphoblastoid cell line [35], a blood cell type as in CD4+ T lymphocytes in the CAMP study; RegulomeDB [36] integrating ENCODE and other sources of annotations for diverse cell types; and SNPs in the National Human Genome Research Institute (NHGRI) GWAS catalog.