PGP and cancer: The EphA10 demonstrateshigh expression in cancers and is correlated with the progressionand malignancy of cancer cells.146 Surfacemodification of nanoparticles with EphA10–antibody enhancestheir cellular uptake, leading to effective inhibition of P-gp andcytotoxicity of DOX.147 Following the designof nanoparticles that are capable of increasing intracellular DOXuptake, the next step should be devoted to developing strategies inreducing the viability and proliferation of cancer cells to maximizethe antitumor activity of DOX.