PTEN and cancer: The PI3K/Akt signaling pathway is avital axis for the proliferation and growth of cancer cells.42 This pathway can be inhibited by an onco-suppressorfactor known as PTEN.43 Studies have demonstratedthat natural products are capable of activating PTEN in suppressingthe PI3K/Akt signaling pathway, thereby decreasing the proliferationand viability of cancerous cells.44 Manunatural products that can target molecular pathways involved in metastasisand invasion of cancer cells.