This isachieved by controlling efflux of chemotherapeutic agents and reducingtheir accumulation in cancer cells that results in chemoresistance.350 The siRNA–ABCB1 effectively suppressesthis transporter and enhances etoposide accumulation in cancer cells,thereby decreasing the viability and proliferation of cancer cells.351 In addition to transporters, genes participatingin the survival of cancer cells may also be targeted. Here, ABCB1 is linked to cancer.