Accordingly, modulation of FAK expressioncan provide new therapeutic venues in inhibiting chemoresistance.313 Surface modification of nanoparticles withhyaluronic acid (HA) enhances their penetration into cancer cellsbecause HA binds to CD44, which is highly expressed on cancer cells.314,315 The HA-modified poly(lactic-co-glycolic acid) nanoparticlesare able to target ovarian cancer cells, and have high cellular uptakebecause they target CD44 receptors. The gene discussed is PTK2; the disease is ovarian cancer.