CASP3 and cancer: Overexpression of HSP27 causes metastasis of cancercells via induction of epithelial–mesenchymal transition.387,388 A combination of resveratrol and siRNA–HSP27 significantlyinhibited the proliferation and migration of glioblastoma cells viadown-regulation of HSP27 and activation of caspase-3, which, in turn,causes apoptosis of the cancer cells.389