BCL2 and cancer: Loading docetaxel and siRNA–p65into nanoparticles significantly suppresses lung metastasis of breastcancer cells via inhibition of MMP-2 and Bcl-2, and stimulation ofapoptosis (Figure 5).248 These studies indicate that nanoplatformsare beneficial in co-delivery of etoposide and siRNAs to enhance internalizationof etoposide by promoting its antitumor activity and suppressing themigration and proliferation of cancer cells.249