The Ras-related C3 botulinum toxin substrate 1 (RAC1)is considered as a key player in the regulation of invasion and metastasisof cancer cells.128,129 The RAC1 attaches to nicotinamideadenine dinucleotide phosphate (NADPH) oxidase (NOX) and increasesthe production of ROS.130 Formation ofactin stress fibers subsequently occurs by cytoskeleton reorganization.131 Down-regulation of RAC1 suppresses metastasisof cancer cells via inhibition of EMT. Here, RAC1 is linked to cancer.