Smallinterfering RNA may be used to knockout the genes involved in malignancy.Vascular endothelial growth factor (VEGF) is an oncogene involvedin enhancing tumor neovascularization and is up-regulated in differenttypes of cancer.357,358 Because of the role of VEGFin promoting cancer growth and viability, studies have been performedon the inhibition of VEGF expression in anticancer therapy.359,360 The combination of siRNA–VEGF and etoposide appears to bebeneficial in the treatment of lung cancer. This evidence concerns the gene VEGFA and lung cancer.