BCL2 and cancer: These nanocarriersinduced apoptosis in cancer cells and reduced their viability andproliferation via down-regulation of Bcl-2 and stimulation of paclitaxel-mediatedapoptosis.302 Gold nanoparticles may alsobe used for the delivery of siRNA because of their adjustable physicochemicalfeatures.303 Bifunctional polyethyleneglycol moieties on the gold nanoparticles enhance targeted deliveryand cellular internalization.304 Thesenanocarriers are used for co-delivery of siRNA–NF-κBand paclitaxel.