Over several decades, numerous CD4 T cell clones in mice and humans have been identified whose MHCII-presented pancreatic epitopes map to several pancreatic β cell granule proteins; however, as with other autoimmune diseases, natural peptides derived from these proteins were often either inactive or only weakly active in stimulating the clones (Dallas-Pedretti et al., 1995; Stadinski et al., 2010a,b; Wang et al., 2018). This evidence concerns the gene CD4 and autoimmune disease.