Management of patients with coronary artery disease and other risk factors, such as diabetes, with novel therapies like sodium-glucose cotransporter 2 inhibitors may reduce the downstream risk of HF.48,49,50,51 In addition, more effective and evidence-based management of AF with rhythm control strategies, such as catheter ablation, may also contribute to lower HF risk. This evidence concerns the gene SLC5A2 and atrial fibrillation.