PDIA3 and breast carcinoma: Considering the above associations of PDIA3 with breast cancer progression and its known ECM glycoprotein substrates, our goal was to investigate the possible role of PDIA3 in pro-metastatic phenotypes of human breast cancer cell lines in vitro, and the possible functional role of secreted proteins that depend on PDIA3 function for their post-translational modification and secretion.