MAPK8 and thyroid cancer, nonmedullary, 2: To determine whether FAM172A plays a critical role through Erk1/2 and JNK MAPK pathways in the pathogenesis of FTC, we examined the changes of MAPK signaling pathway-related proteins including Erk1/2, p-Erk1/2, JNK and p-JNK using immunoblotting in both FTC-133 and FTC-238 cells.