LGALS3 and multinodular goiter: However, another study found that the galectin-3 was expressed not only in the majority of PTC and FTC, but also expressed in FTA, multinodular goiters, normal thyroid tissue and Hashimoto’s thyroiditis, which indicates that galectin-3 is not a reliable marker to differentiate malignant from benign thyroid follicular lesions (Mehrotra et al. 2004).