Only tissue‐specific premature aging phenotypes, including cataracts, have been reported in those MVA syndromes, while Bubr1 hypomorphic mice show MVA and systemic premature aging phenotypes, including kyphosis, muscle atrophy, dermal thinning, heart failure, and loss of fat tissues (Baker et al., 2004). The gene discussed is BUB1B; the disease is mosaic variegated aneuploidy syndrome 1.