SOX2 and cancer: Another possible explanation is that the systemic premature aging phenotype is related to the non‐mitotic function of the APC/CCDC20 associated with the maintenance of stem cells, which is shown in a model of cancer stem cells where APC/CCDC20 is associated with self‐renewal activity of stem cells by interacting with pluripotency‐related transcription factor SOX2 (Mao et al., 2015).