It has been reported that overexpression of IGF2BP3 increased phosphorylation of IκBα and knockdown of IGF2BP3 reduced activation of IκBα in renal cell carcinoma (RCC) cells, indicating that IGF2BP3 activates the NF‐κB signalling pathway and promotes RCC cell migration and invasion.32 Here, NFKB1 is linked to hereditary clear cell renal cell carcinoma.