It has been reported that overexpression of IGF2BP3 increased phosphorylation of IκBα and knockdown of IGF2BP3 reduced activation of IκBα in renal cell carcinoma (RCC) cells, indicating that IGF2BP3 activates the NF‐κB signalling pathway and promotes RCC cell migration and invasion.32 This evidence concerns the gene IGF2BP3 and hereditary clear cell renal cell carcinoma.