BRAF and IDH1, plotted in Figure 4, are predicted as having a more specific influence by cancer type, with a high percentage incidence of predicted SNV-drivers embedded in BRAF for skin cutaneous melanoma (44.8% of cases (typecode:SKCM)), thyroid cancer (55.8%, THY) and colon adenocarcinoma (13.4%, COAD). The gene discussed is BRAF; the disease is cancer.