Prenatally androgenized (PNA) mice, which reflect the cardinal features and neuroendocrine impairments of PCOS [20], display a greater frequency of GABAergic postsynaptic currents in GnRH neurons [13, 15] and elevated GnRH neuron firing frequency [15, 19, 21] compared with fertile controls. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.