Studies have suggested that CRKL contributes pivotal roles in malignancy of human cancers such as glioblastoma (Lv et al., 2013), breast cancer (Zhao et al., 2013), and colon cancer (Lan et al., 2014), among others (Tsuda et al., 2004; Brabek et al., 2005; Mortazavi et al., 2011; Guo et al., 2014). Here, CRKL is linked to malignant colon neoplasm.