Our recent study showed that CRKL is highly expressed in IHC of hepatocarcinoma patient tissue samples and HCC cells and is negatively regulated by miR-429 overexpression (Guo et al., 2018, 2020); we demonstrated that the CRKL protein level was overexpressed and miR-124-3p was downexpressed in tumorous tissues of HCC patients, which provided a negative correlation between CRKL and miR-124-3p alterations. This evidence concerns the gene CRKL and hepatocellular carcinoma.