Besides these, also based on the evidence that CRKL was a straight downstream protein of miR-124-3p, the expression of CRKL was highly suppressed in HCC cells by miR-124-3p and the inverse correlation of miR-124-3p deficiency with CRKL upregulation in HCC tumorous tissues indicates that miR-124-3p together with its target binding with CRKL forms an important axis regulation mechanism in HCC malignancy. The gene discussed is CRKL; the disease is hepatocellular carcinoma.