OSBP2 and Abnormal sperm morphology: In previous studies, oxysterol-binding protein 2 (OSBP2) has been elucidated playing an important role in the postmeiotic differentiation of germ cells and would cause male infertility owing to oligo-astheno-teratozoospermia with lack of OSBP2 (ORP4) (Charman et al., 2014; Udagawa et al., 2014).