Dominant OI is caused by mutations in COL1A1 or COL1A2, and phenotypes can vary from mild to moderate/severe depending on the whether the collagen defect was caused by haplo-insufficiency or helical mutations that led to dominant negative effect (Rauch et al., 2010; Lindahl et al., 2015). This evidence concerns the gene COL1A1 and osteogenesis imperfecta.