Chopra et al. (2020) suggested that dysregulation of miRNA-298, which down-regulates the expression of amyloid precursor protein (APP) and beta-secretase 1 mRNAs, may play important roles in the incidence and progression of AD, especially since changes in miRNA-298 levels in the blood and CSF of AD patients have been observed. This evidence concerns the gene APP and Alzheimer disease.