Similar results were obtained in a model of diabetic neuropathy, the densities of total A-currents were markedly reduced in medium- and large-, but not in small-diameter DRG neurons and this was matched by changes in mRNA levels for Kv1.4, Kv3.4, Kv4.2, and Kv4.3 (Cao et al., 2010). This evidence concerns the gene KCNA4 and diabetic neuropathy.