FUS and juvenile amyotrophic lateral sclerosis: For instance, mutations in SOD1, TDP-43, C9ORF72, FUS, ANG, OPTN, UBQLN2, and ATXN2 have recently been identified in classical ALS, while mutations in FUS, SIGMAR1, SPG11, ALS2, SOD1, C19ORF12, DDHD1, SETX, and TARDBP were detected in patients with JALS (Avemaria et al., 2011; Daoud et al., 2012; Siddiqi et al., 2014; Wu and Fan, 2016; Liu et al., 2017; Ma et al., 2018; Naumann et al., 2019).