FUS and amyotrophic lateral sclerosis: We have previously described a novel heterozygous mutation in exon 14 of the FUS gene, c.1509dupA (p.R503fs), chromosome 16, of a 17-year-old girl who had been diagnosed with ALS based on the clinical manifestations, and who had subsequently died of respiratory failure 15 months after onset (Chen et al., 2020).