These findings could suggest the possible use in the HIV setting of the known drugs, which target HER2 and downstream proliferative signaling pathways, as trastuzumab, pertuzumab, trastuzumab emtansine (T-DM1) and lapatinib, used clinically in treating HER2+ breast cancer [48–50]. The gene discussed is ERBB2; the disease is breast carcinoma.