Given the larger numbers of these epigenetically altered CD4+CLA+ T cells in the skin of patients (Fig. 6b) and the recirculation of these cells, we hypothesize that the epigenetic alterations detected in CLA+ T cells from peripheral blood promote pro-inflammatory functions in skin of patients and contribute to AD immunopathology (Fig. 6d). The gene discussed is SELPLG; the disease is Alzheimer disease.