Two other genes from the F-box family (FBXO18 and FBXO24) implicated in protein ubiquitination were found differentially methylated in AD patients (Table 2), altogether suggesting that genes implicated in protein ubiquitination are epigenetically altered in CD4+CLA+ T cells from AD patients, and may promote inflammation by altering signaling. Here, FBXO24 is linked to Alzheimer disease.