Some of the differentially methylated genes in CD4+CLA+ T cells of AD patients are implicated as key regulators of cytokine signaling pathways and immune inflammation (ARHGEF3, ASB2, DAPP1, IL10RA, PDE4A, SH2B3, STIM1 and TOX2, Fig. 1c). Here, ASB2 is linked to Alzheimer disease.