These results refined the signals detected in GPR55, MAN1A1 and CDHR3 by using the DMP analysis (Table 2) and uncovered methylation differences in the genes encoding the transcription factor estrogen receptor alpha (ESR1) and the nuclear receptor co-repressor 2 (NCOR2) (Table 3), suggesting that in AD patients the epigenome of circulating CD4+CLA+ T cells is affected in regions encoding transcription factors. Here, ESR1 is linked to Alzheimer disease.