In agreement with Han et al.64, we found almost no differences in DNA methylation levels between CD4+ naïve T cells from AD patients compared to HC (Fig. 1a); neither in the unfractionated CD4+ T cells as described by Rodriguez et al.11, nor in CD8+ T cells supporting that epigenetic alterations are principally detected in CD4+CLA+ T cells. The gene discussed is SELPLG; the disease is Alzheimer disease.