Our results revealed for the first time a significant inverse correlation between reduced DNA methylation in the IL13 promoter and increased IL13 mRNA expression in CD4+CLA+ T cells of AD patients (Fig. 2c), providing insights into the molecular events that might lead to the remarkable ability of CLA+ T cells from AD patients to secrete IL-1322,24,44. The gene discussed is SELPLG; the disease is Alzheimer disease.