These analyses highlighted ESR1 as a target of several AD upregulated miRNAs, involved in several processes such as cell differentiation and migration, transforming growth factor beta receptor signaling pathway and T cell differentiation (Supplementary Table S2 online); suggesting for the first time that this transcription factor is a dysregulated mediator of several putative disturbed pathways in CLA+ T cells from AD patients. This evidence concerns the gene ESR1 and Alzheimer disease.