Because of a specific disease phenotype of Casq2 mutants, one a priori prediction is that the mutations associated with CPVT would be in sites conserved in Casq2 but divergent in Casq1 and preduplicates, providing gain-of function amino acid changes in Casq2 which were then disrupted by the disease phenotype-associated mutations. Here, CASQ2 is linked to catecholaminergic polymorphic ventricular tachycardia.