CASQ2 and catecholaminergic polymorphic ventricular tachycardia: For our biochemical studies, we have selected mutants linked to the human CPVT phenotype and located within highly conserved positions, namely, R33Q, L167H, K180R, D307H and three CASQ2 variants from whole-exome sequencing clinical testing, P329S, G332R, and D351G24–27,39,46,62,63.