TXN and catecholaminergic polymorphic ventricular tachycardia: Furthermore, we carried out biochemical and biophysical analysis of seven CPVT related mutants (R33Q, L167H, D307H, K180R), and whole exome sequencing variants (D351G, G332R, P329S) selected based on their linked to the human CPVT phenotype and located within highly conserved thioredoxin-like domain.