In F1, this dose also produced fasting hyperglycemia, glucose intolerance, insulin insensitivity and low plasma insulin in exposed F1 (Fig. 4), suggesting the possibility that DE-71 actions on glucose intolerance and insulin reduction and upregulation of the sympathoadrenal system may be related since diabetic animals show elevated adrenal epinephrine produced in chromaffin cells58. Here, INS is linked to Hyperglycemia.