INS and Glucose intolerance: In F1, this dose also produced fasting hyperglycemia, glucose intolerance, insulin insensitivity and low plasma insulin in exposed F1 (Fig. 4), suggesting the possibility that DE-71 actions on glucose intolerance and insulin reduction and upregulation of the sympathoadrenal system may be related since diabetic animals show elevated adrenal epinephrine produced in chromaffin cells58.