CCN2 and pulmonary fibrosis: As a whole our results show, by the first time, that the administration of liraglutide in the precocious initial phase of lung fibrosis, reduces collagen interstitial deposition and production of precursor materials as proline and hydroxyproline, reduces presence of myofibroblasts in the tissues and the expression of pro-fibrotic cytokines as Tgfb1 and Ctgf. Moreover, liraglutide modulates de activity of the pulmonary angiotensins and their receptors improving lung vascular conditions and preventing right ventricle hypertrophy.